the stage and spacing
Centre stage lends itself to being able to be seen by the enire audience and has a focal point to keep the audience's attention. choreography can be staged symmetrically making it aesthetically pleasing and enjoyable to watch; choreograph would be easier based around the centre of the skene also.
However being closer to the audience in the orchestra increases the intimacy and therefore empathy created by the audience for the action on stage. It involves the audience more, whereas standing by the central back of the skene distances the audience; there is less space though for the chorus to move in, and the movements would have to be more restricted as a result.
ii. The spacial differences can affect the meaning of the scene; for example empathy could occur between certain characters and the audience which may not have happened if the actors had been placed further back nearer the skene. It means that the audience will react differently to subsequent scenes as they will be able to relate to certain characters' viewpoints better and may have a biased view because of this.