December 26, 2005

Conclusion

Other possible treatments in the future, mass screening programs, new drugs, proposed drug treatments, the future for H.Pylori, other news on H.Pylori etc

Treatment (of ulcers)

Structure of each section:

  1. Explain method of action of each drug type
    This may include a metabolic pathway of the drug etc
  2. Development history
  3. Side effects
  4. Drug resistance
  5. Choose 1 example and talk about synthesis and cost
  6. Tabulate other drugs in class and tabulate the regimens

Antibiotics

Amoxicillin, Clarithromycin (Biaxin), Metronidazole (Flagyl), Tetracycline

H pylori antibiotic resistance: prevalence, importance, and advances in testing F Mégraud

H2 blockers

Cimetidine (Tagamet), Famotidine (Pepcid), Nizatidine (Axid), Ranitidine (Zantac)

www.medicinenet.com/cimetidine/article.htm

Proton Pump Inhibitors

Aciphex, Nexium, Prevacid, Prilosec, Protonix

Other

Cytoprotective Agents: Bismuth subsalicylate, sucralfate, Bi-citrate
Combination Products: Helidac, Prevpac

Do we do treatments for the other diseases?


Diseases

  • Definition, effect (and histology?)

Duodenal and stomach ulcers

Gastric Cancer

Functional dyspepsia

Other

>>>>>>>>>

Diagnosis

www.helico.com


December 25, 2005

Introduction

  1. Introduction of H. pylori
  2. Epideomology of H pylori
  3. Economics- costs pre and post H. Pylori discovery.
  4. Treatment prior to H. pylori discovery
  5. Robin Warren's and Barry Marshall's discovery
    -Marshall BJ. Unidentified curved bacillus on gastric epithelium in active chronic gastritis. Lancet 1983;1((8336):1273–1275.
    -Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach patients with gastritis and peptic ulceration. Lancet 1984;1
    (8390):1311–1315.

  6. How infection occurs, H. pylori mechanism in causing stomach ulcers.

Answers.com has some of the primary reference sources and other good links.

Excellent review, gives an overview inc. epideomology

Another Review 4 H.pylori to find the articles in the journal).

Mechanism


November 21, 2005

Minutes

Date: Monday 31st October 2005 Time: 2.30pm

Minutes taken by Jaimini Patel

Present: Jaimini Patel, Nana Muhammad, James Morris, Yiling Luo and Imran Malik

In the first meeting we discussed the possible topics we wish to cover, and how to tackle the essay title.

The topics to look at were as follows:
History & discovery: Yiling Luo & James Morris
Biological effects of the bacterium: Nana Muhammad
Treatment of Helicobacter pylori: Imran Malik & Jaimini Patel

Additional information that was already known: _Heilicobacter pylori _ is a bacterium found in the stomach and is a cause of stomach ulcers and cancer. It was discovered by Australians.

Date: Monday 7th November 2005 Time: 2pm

Minutes taken by Nana Muhammad

Present: Jaimini Patel, Nana Muhammad, James Morris, Yiling Luo and Imran Malik

In the second meeting we presented our research to each other: James discussed his findings about the discovery of H. pylori. He had also researched how to diagnose its existence/percentage of people in the world who have it. He also found out about how H. pylori survives and manages to live in acidic conditions of the stomach eg. HP producing ammonia to neutralise acid. He mentioned the genetic variation of H.P Yiling had also researched discovery and found much similar information to James. She had some particularly good diagrammatic representations of her findings.

Jaimini discussed treatment types: how antibiotics are important and the need for differing treatment if the individual has stomach cancer. She had a useful table of therapies which will be good for the presentation. Imran had looked at treatment as well, and had found information on triple drug therapies and how research is being undertaken regarding the quadruple drug therapies. He also discussed the resistance of Helicobater pylori to mono/bi therapies and diagnosis of the infection eg. blood, antibodies, urea, stool, endoscopic tests. He had infomation on H2 blockers, proton pump inhibitors and PPIs.

Nana had found information on the histology of the stomach itself and its structure. She also had some information on ulcers themselves and on Helicobacter pylori and its bacterial structure.

We decided that it was important to focus on the chemistry and biology of Helicobacter pylori eg. finding mechanisms and chemical structures.

We agreed to set up a Blog, an easy way for everyone to access all of the information that we had collectively found.

Topics to be researched in greater detail were allocated: James was to look up antibiotics, Jaimini was to research H2 blockers, Imran was to research PPIs/diagnosis, Nana was to research stomach lining, any chemical mechanisms of stomach and other illnesses involved with Helicobacter pylori and Yiling was to research the discovery of Helicobacter pylori and its life cycle.

Next meeting Monday, time to be confirmed. Location, chem. Computer room

Date: Monday 14th November 2005 Time: 11.30am

Minutes taken by Nana Muhammad

Present: Jaimini Patel, Nana Muhammad, James Morris, Yiling Luo and Imran Malik

In the third meeting, we talked about relevant sites to find journals as we were having some difficulty accessing various journals.

We came up with the idea of possibly using Rasmol to help show structures of proteins that are inhibited by drugs-this would also be useful for the presentation. We decided to collate as much relevant information as possible by Friday Week 9, so that we would have enough time should any problems arise before the final essay deadline.

Topics to be collated in greater detail were H2 blockers and diagnosis to be researched by Jaimini, PPIs to be researched by Imran, antibiotics to be researched by James, discovery of H. pylori and bacteria structure to be researched by Yiling and structure of stomach and ulcer structure for Nana. We exchanged contact details for easier networking of information.

Next meeting, time to be confirmed. Location, chem. Computer room

Date: Monday 25th November 2005 Time: 12.00pm

Minutes taken by Nana Muhammad

Present: Jaimini Patel, Nana Muhammad, James Morris, Yiling Luo and Imran Malik

In the fourth meeting we discussed our progress and as we had found more relevant topics we assigned those to everyone. We have given ourselves a deadline for the first rough draft of the essay for Wednesday Week 11.

We have also produced a formatting document so that each member of the group’s separate portions of the essay will be similar in style, making it easier to form one coherent essay.

Date: Thursday 1st December 2005 Time: 12.00pm

Minutes taken by Nana Muhammad

Present: Jaimini Patel, Nana Muhammad, James Morris, Yiling Luo and Imran Malik

In the fifth meeting we met up to write the progress report. We have a preliminary timetable for next term, continuing our weekly meetings. We plan to complete the presentation by Week 12.


Its up and running

Ladies and gent, H. Pylori blog is up and ready to go.

Enjoy!


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