All entries for August 2017

August 19, 2017

Trial results infographics

There is a fashion for producing eye-catching infographics of trial results. This is a good thing in some ways, because it’s important to get the results communicated to doctors and patients in a way they can understand. Here’s one from the recent WOMAN trial (evaluating tranexamic acid for postpartum haemorrhage).

WOMAN trial 2

What’s wrong with this? To my mind the main problem is that if you reduce the messages to a few headlines then you end up leaving out a lot of pretty important information. One obvious thing missing from these results is uncertainty. We don’t know, based on the trial’s results, that the number of women bleeding to death would be reduced by 30% – that’s just the point estimate, and there’s substantial uncertainty about this.

Actually the reduction by 30% isn’t the trial’s main result, which has the risk ratio for death due to haemorrhage as 0·81, 95% CI 0·65–1·00. So that’s actually a point estimate reduction of 19%, with a range of effects “consistent with the data” (or not significantly different from the data) of a reduction between 35% and zero. The 30% reduction seems to come from a subgroup analysis of women treated within 3 hours of delivery. A bit naughty to use a subgroup analysis as your headline result, but this highlights another problem with the infographic – you don’t really know what you’re looking at. In this case they have chosen to present a result that the investigators presumably feel represents the real treatment effect – but others might have different views, and there isn’t any way of knowing that you’re seeing results that have been selected to support a particular story.

[I’m guessing that the justification for presenting the “<3 hour” subgroup is that there wasn’t a clear effect in the “>3 hour” subgroup (RR 1.07, 95% CI 0.76, 1.51), so the belief is that treatment needs to be given within 3 hours to be effective. There could well be an effect of time from delivery, but it neds a better analysis than this.]

WOMAN trial: Lancet, Volume 389, No. 10084, p2105–2116, 27 May 2017

PS And what’s with the claim at the top that the drug could save 1/3 of the women who would otherwise die from bleeding after childbirth? That’s not the same as 30%, which wasn’t the trial’s result anyway. I guess a reduction of 1/3 is a possible result but so are reductions of 25% or 10%.

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  • Hi Tom Sorry for delay in replying – taken out by family issues then holiday for the last month or s… by Simon Gates on this entry
  • Simon, I can see where you're coming from on this. If MCID (in its various guises) is not an optimal… by Chee-Wee Tan on this entry
  • Hi Simon I am currently doing my PhD in clinical based research. We want to use the MCID to determin… by tomwilks on this entry
  • I think your comment reveals how nonsensical null hypothesis testing is (and I see from your other p… by matt on this entry
  • Thanks for commenting Matt – I do wonder if anyone ever looks at any of this, not that this is a pro… by Simon Gates on this entry

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