Pointillist is a collection of programs for inferring the set elements affected by a perturbation of a biological system, based on a collection of evidences. It contains four programs: Data Manager, Data Normalizer, Significance Calculator, and Evidence-Weighted Inferer. First two are for data retrieval,manipulation and normalization. The Significance Calculator is a program that can analyze the probability distribution of a set of observations, and compute the statistical signficance of each observation on the basis of the distribution.The Evidence-Weighted Inferer is a classification program that attempts to divide a set of elements into two sets, affected and unaffected. It compares multiple evidences to determine which elements of a network are most likely affected by a perturbation of a system.Overall, just another machine-learning program.