Neural Induction; Reference list 2005
- Harland, R. (2000) Current Opinions in Genetics and Development 10, 357–362
- Stern (2005) Development 132, 2007–2021
Neural induction: old problem, new findings, yet more questions.
- De Robertis, E.M., Kuroda, H. (2004) Annu Rev Cell Dev Biol 20, 285–308
Dorsal-Ventral patterning and neural induction in xenopus embryos
Regional properties of the nervous system and planar induction
- Doniach, T. et al. (1992) Science 257, 542–545
Planar induction of anteroposterior pattern in the developing central nervous system of xenopus laevis
Molecules involved in induction of anterior nervous system
- Lamb, T.K. et al. (1993) Science 262, 713–718
Neural induction by the secreted polypeptide Noggin.
- Knecht, A.K. et al. (1995) Development 121, 1927–1936
Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm.
- Hemmati-Brivanlou, A., Melton D.A. (1994) Cell 77, 273–281
Inhibition of activin receptor signaling promotes neuralization in xenopus.
- Hemmati-Brivanlou, A. et al. (1994) Cell 77, 283–295
Follistatin, an antagonist of activin, is expressed in the spemann organizer and displays direct neutralizing activity.
- Sasai et al. (1995) Cell 79, 779–790
Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes.
- Hansen et al. (1997) Development 124, 483–492
Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3.
- Bouwmeester et al. (1996) Nature 382, 595–601
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. (abstract only)
Mechanism by which activation molecules work
- Zimmerman et al. (1996) Cell 86, 599–606
The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4.
- Piccolo et al. (1996) Cell 86, 589–598
Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4.
- Iemura et al. (1998) PNAS 95, 9337–9342
Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo.
- Piccolo et al. (1999) Nature 397, 707–710
The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals.
- Hawley et al. (1995) Genes and Development 9, 2923–2935
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. (abstract only)
Candidate molecules for the posteriorising signal, transformation
- Lamb and Harland (1995) Development 121, 3627–3636
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern.
- Doniach (1995) Cell 83, 1067–1070
Basic FGF as an inducer of anteroposterior neural pattern.
- Kroll and Amaya (1996) Development 122, 3173–3183
Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation.
- Blumberg et al. (1997) Development 124, 373–379
An essential role for retinoid signaling in anteroposterior neural patterning.
Other candidate inducing molecules
- LeSueur and Graff (1999) Development 126, 137–146
Spemann organizer activity of Smad10.
- Strong et al. (2000) Developmental Biology 222, 405–419
Xbra3 induces mesoderm and neural tissue in Xenopus laevis.
- Delaune et al. (2005) Development 132, 299–310
Neural induction in Xenopus requires early FGF signalling in addition to BMP inhibition.
Morpholino knock-down experiments
- Khokho et al. (2005) Developmental Cell, 401–411
Depletion of Three BMP Antagonists from Spemann's Organizer Leads to a Catastrophic Loss of Dorsal Structures.
- Reversade et al. (2005) Development e press 23/6/2005
Depletion of Bmp2, Bmp4, Bmp7 and Spemann organizer signals induces massive brain formation in Xenopus embryos.
And, as is quickly becoming tradition, the obligatory cute kitten picture