July 25, 2008

Diary of a randomised controlled trial 25 July 2008

This diary is partly for my own amusement, but also to record the enormously long drawn-out process of setting up and running a large scale randomised controlled trial.

We (which is the Warwick Medical School Clinical Trials Unit) were lucky enough to be awarded funding a few weeks ago by the NIHR Health Technology Assessment Programme for a randomised controlled trial of the LUCAS mechanical compression device for cardiac arrest. Briefly, this is a mechanical device for providing chest compressions for people who have had a cardiac arrest. Its suggested advantages over standard manual compression is that it doesn't tire so the quality of compressions remains constant, it can operate in situations where a paramedic wouldn't be able to do manual compressions (such as when a patient is being moved) and it frees up paramedics to do other important jobs, like saving other people. But there is no evidence that it actually does save peoples' lives and it's also possible that it kills them; for example, it might cause internal injuries that cause more people to die later on. Hence the need for the trial, which we are doing in collaboration with Coventry University, Leeds University and the West Midlands and Scottish Ambulance Services.

We were awarded this grant at the end of June 2008 but the project was already over a year old by then. The original idea to do this trial came up in meetings towards the end of 2006 and we submitted an outline proposal in May 2007. Just after we had done this there was a call for proposals in the field of Emergency and Prehospital care, and the funding body suggested to us that we should move our application into this funding stream, which we agreed to. However, it became clear that there was another application for a trial of the same device so we had some direct competition. As a result of the outlines we were invited to submit a full application, which went in in February 2008.

So we are now finally at the point of having the money and having to deliver this trial.


- No comments


Add a comment

Name
Email
Anti-Spam Question
My t-shirt is red. What colour is my t-shirt?
Anti-Spam Answer
Comment


Your IP address will be recorded. -

You can not use HTML, but you can use our special markup -

July 2008

Mo Tu We Th Fr Sa Su
|  Today  | Aug
   1 2 3 4 5 6
7 8 9 10 11 12 13
14 15 16 17 18 19 20
21 22 23 24 25 26 27
28 29 30 31         

Search this blog

Tags

Galleries

Most recent comments

  • Hi Tom Sorry for delay in replying – taken out by family issues then holiday for the last month or s… by Simon Gates on this entry
  • Simon, I can see where you're coming from on this. If MCID (in its various guises) is not an optimal… by Chee-Wee Tan on this entry
  • Hi Simon I am currently doing my PhD in clinical based research. We want to use the MCID to determin… by tomwilks on this entry
  • I think your comment reveals how nonsensical null hypothesis testing is (and I see from your other p… by matt on this entry
  • Thanks for commenting Matt – I do wonder if anyone ever looks at any of this, not that this is a pro… by Simon Gates on this entry

Blog archive

Loading…
Not signed in
Sign in

Powered by BlogBuilder
© MMXVII